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Background The metabolic syndrome (MS) is termed a cluster of multiple metabolic risk criteria which is positively correlated with cardiovascular disease and type 2 diabetes mellitus (DM). Yam dioscorins have been reported to exhibit biological activities, however, little is known their preventive effects on the MS. Therefore, a high-fat (HF) diet was used to induce Wistar rat obesity and then...
The purified dioscorin from yam (Dioscorea alata L. cv. Tainong 1) tuber was previously reported (Hsu et al., 2002. J. Agric. Food Chem., 50, 6109–6113). In this report, we evaluated its immunomodulatory ability in vitro in the presence of polymyxin B (50μg/ml) to eliminate lipopolysaccharide (LPS) contamination. Dioscorin (5–100μg/ml) was able to stimulate nitric oxide production (expressed as nitrite...
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