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We previously observed that 17β-estradiol (E2) augments ischemic borderzone vascular density 10days after focal cerebral ischemia–reperfusion in rats. We now evaluated the effect of E2 on vascular remodeling, lesional characteristics, and motor recovery up to 30days after injury. Peri-lesional vascular density in tissue sections from rats treated with 0.72mg E2 pellets was higher compared to 0.18mg...
Peri-infarct increase of vascular density has been observed in animals and in humans with ischemic stroke. Increased peri-infarct vascular density correlates with improved functional outcome after stroke. We hypothesized that pre-treatment with estradiol will increase post-ischemic peri-infarct capillary density in a rat model of transient ischemic stroke. Estradiol, compared to placebo, augmented...
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