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Rabbit articular chondrocytes in monolayer culture were stimulated with human recombinant interleukin-1β. Under the influence of the cytokine the intracellular pool of the cysteine endopeptidase cathepsin B was increased by a 2-4-fold factor, while enzyme secretion was not stimulated at a significant level. Under the same conditions, the secretion of collagenase, measured as an internal control, was...
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