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Phosphorothioate compounds are widely used in agriculture and public health for the control of unwanted pests. The phosphorothioate parathion was metabolised to the toxic metabolite paraoxon (0.0380.683nmol/min per mg protein) and p-nitrophenol (0.0232.10nmol/min per mg protein) by human liver microsomes (n=27) in an NADPH-dependent reaction. There was a significant correlation (P0.02) between nifedipine...
Human liver microsomes (n=16) activated parathion (O, O, diethyl O-p-nitrophenyl phosphorothioate, 20 and 200 μM) to paraoxon at a rate of 23.3-199.3 and 18.7-310.3 pmol/min per mg protein, respectively. p-Nitrophenol, was also formed, at 321.1-769.2 and 406.2-778.3 pmol/min per mg protein. This represented a 16-fold and 2-fold range in capacity to activate and detoxify parathion, respectively. Parathion...
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