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The pH-responsive polypeptide grafted with polycation was prepared through copper(I)-catalyzed “click chemistry”. The amphiphilic polypeptide directly formed into cationic vesicle when it was dissolved in phosphate buffer solution (PBS). The hydrophilic DOX·HCl was loaded into the hollow core of vesicle. The in vitro release behavior of DOX·HCl from vesicle in PBS could be adjusted by the pH of release...
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