Search results for: Toru Maruyama

Items from 1 to 20 out of 182 results

article

Case series of bradycardia, renal failure, atrioventricular nodal blockers, shock and hyperkalemia syndrome in patients with dementia

Toru Maruyama, Seiji Kondo, Hideyuki Nomura

Geriatrics & Gerontology International > 24 > 7 > 737 - 738

article

Constipation and heart failure: An overlooked but important linkage

Toru Maruyama, Michinari Hieda, Kunimitsu Eiraku, Yuki Uozumi, more

Geriatrics & Gerontology International > 23 > 3 > 255 - 256

article

A senile case of heart failure associated with hypermagnesemia induced by magnesium‐containing laxative agent

Kunimitsu Eiraku, Yuki Uozumi, Michinari Hieda, Toru Maruyama, more

Geriatrics & Gerontology International > 22 > 10 > 897 - 899

article

A Mannosylated, PEGylated Albumin as a Drug Delivery System for the Treatment of Cancer Stroma Cells

Yuki Mizuta, Hitoshi Maeda, Yu Ishima, Yuki Minayoshi, more

Advanced Functional Materials > 31 > 43 > n/a - n/a

Mannose receptors that are expressed on macrophages and fibroblasts in cancer stroma are promising therapeutic targets for cancer treatment. Albumin can be used as a drug carrier in chemotherapeutics due to its accumulation in the tumor tissue by the enhanced permeability and retention effects. A mannosylated albumin was recently developed as a new drug carrier targeting cells that express mannose...

article

Evaluation of a new measurement method of indoxyl sulfate in hemodialysis patients

Takaya Abe, Mitsutaka Onoda, Tomohiko Matsuura, Jun Sugimura, more

Therapeutic Apheresis and Dialysis > 25 > 1 > 44 - 49

Indoxyl sulfate (IS) is related to the development of cardiovascular disease and total mortality in dialysis patients. High‐performance liquid chromatography (HPLC) is the conventional measurement approach. However, the HPLC method is difficult to perform in real time. Recently, the IS Assay Kit “NIPRO”, which enables the measuring of total IS by the enzyme method, was developed. This new reagent...

article

Albumin domain mutants with enhanced Aβ binding capacity identified by phage display analysis for application in various peripheral Aβ elimination approaches of Alzheimer's disease treatment

Yu Ishima, Ai Mimono, Victor Tuan Giam Chuang, Tetsuya Fukuda, more

IUBMB Life > 72 > 4 > 641 - 651

Deposition of amyloid protein, particularly Aβ_1‐42, is a major contributor to the onset of Alzheimer's disease (AD). However, almost no deposition of Aβ in the peripheral tissues could be found. Human serum albumin (HSA), the most abundant protein in the blood, has been reported to inhibit amyloid formation through binding Aβ, which is believed to play an important role in the peripheral clearance...

article

Prognostic significance of red cell distribution width in hospitalized older patients with heart failure or infection

Keitaro Nakashima, Eiichi Ohgami, Kazuhiko Kato, Souichi Yoshitomi, more

Geriatrics & Gerontology International > 19 > 10 > 988 - 992

Aim Red cell distribution width (RDW) is a simple, sensitive and cost‐effective parameter, and is associated with pathophysiology of many common diseases. The aim of the present study was to investigate the prognostic role of RDW in older adults hospitalized for the treatment of heart failure (HF) or infection, because both diseases are fatal, especially in the geriatric population. Methods This...

article

Effect of Molten Metal Temperature on Mold Filling in Evaporative Pattern Casting

Toru Maruyama, Mitsuyoshi Tamaki, Gou Nakamura, Keisuke Nakamura

International Journal of Metalcasting > 2019 > 13 > 3 > 611-617

The mold filling rate during evaporative pattern casting was measured in a wide range of molten metal temperatures from 800 to 1450 °C. A polystyrene columnar foam was used as the foamed pattern, and bottom pouring was applied to design the casting. Tin alloy, copper alloy, and cast iron were used as molten metals to vary the molten metal temperature. The mold filling rate increased with increasing...

article

Influence of Tellurium Addition to Spheroidal Graphite Cast Iron on the Number of Graphite Particles

Ryuta Saito, Toru Maruyama, Toshiki Nakamura, Hitoshi Yanagitani, more

International Journal of Metalcasting > 2019 > 13 > 3 > 571-577

Influences of magnesium content on the actions of tellurium to graphite nodule count and chilling tendency in spheroidal graphite cast iron are investigated. Casting samples 30 mm in diameter were prepared by lab size induction furnace melting. On castings with two levels (0.020 mass% and 0.035 mass%) of magnesium content, tellurium content was changed from 0 to 45 mass ppm. With additions of a small...

article

Antioxidant activities of chitosans and its derivatives in in vitro and in vivo studies

Makoto Anraku, Janusz M. Gebicki, Daisuke Iohara, Hisao Tomida, more

Carbohydrate Polymers > 2018 > 199 > C > 141-149

This review focuses on the in vitro and in vivo antioxidant activities of various chitosan preparations, including those with different molecular weights and degrees of acetylation and the nanofibers produced from them. In in vitro studies, low molecular weight (LMW) chitosan with high degrees of deacetylation has more potent antioxidant properties than those of high molecular weight (HMW) chitosan...

article

A metabarcoding survey for seasonal picophytoplankton composition in two coral reefs around Sesoko Island, Okinawa, Japan

Handung Nuryadi, Thi Tra My Nguyen, Michihiro Ito, Naoko Okada, more

Journal of Applied Phycology > 2018 > 30 > 6 > 3179-3186

Okinawa is the southwesternmost part of Japan and represents the northern limit of coral reefs that are influenced by the Kuroshio warm current. We have been studying two coral reefs off Sesoko Island, in northern Okinawa, to evaluate coral reef environments since 2014. In this study, we applied a metagenomic approach to analyze the seasonal composition of picophytoplankton at these two reef sites...

article

Role of Parathyroid Hormone in Regulating Transporter and Metabolizing Enzyme Function

Hiroshi Watanabe, Toru Maruyama

Therapeutic Apheresis and Dialysis > 22 > 3 > 251 - 254

Recent studies demonstrate that parathyroid hormone (PTH) not only maintains mineral homeostasis through targeting the kidneys and bone, but also exerts its effects on other organs. For instance, PTH induces urate accumulation through inhibiting the expression of the ABCG2 in both the intestine and the kidney. In addition, PTH downregulates the expression of cytochrome P450 (CYP) 3A, a major enzyme...

article

Does the prenatal bisphenol A exposure alter DNA methylation levels in the mouse hippocampus?: An analysis using a high-sensitivity methylome technique

Toshiki Aiba, Toshiyuki Saito, Akiko Hayashi, Shinji Sato, more

Genes and Environment > 2018 > 40 > 1 > 1-8

Background There is still considerable debate about the effects of exposure to bisphenol A (BPA) an endocrine disrupter at low doses. Recently, many studies using animal models have shown that prenatal BPA exposure induces behavioral and neuronal disorders due to epigenetic changes in the brain. However, striking evidence of epigenomic changes has to be shown. Methods To investigate whether low-dose...

article

Thioredoxin-albumin fusion protein prevents copper enhanced zinc-induced neurotoxicity via its antioxidative activity

Ken-ichiro Tanaka, Mikako Shimoda, Victor T.G. Chuang, Kento Nishida, more

International Journal of Pharmaceutics > 2018 > 535 > 1-2 > 140-147

Zinc (Zn) is a co-factor for a vast number of enzymes, and functions as a regulator for immune mechanism and protein synthesis. However, excessive Zn release induced in pathological situations such as stroke or transient global ischemia is toxic. Previously, we demonstrated that the interaction of Zn and copper (Cu) is involved in the pathogenesis of Alzheimer’s disease and vascular dementia. Furthermore,...

article

2016 SOSORT guidelines: orthopaedic and rehabilitation treatment of idiopathic scoliosis during growth

Stefano Negrini, Sabrina Donzelli, Angelo Gabriele Aulisa, Dariusz Czaprowski, more

Scoliosis and Spinal Disorders > 2018 > 13 > 1 > 1-48

Background The International Scientific Society on Scoliosis Orthopaedic and Rehabilitation Treatment (SOSORT) produced its first guidelines in 2005 and renewed them in 2011. Recently published high-quality clinical trials on the effect of conservative treatment approaches (braces and exercises) for idiopathic scoliosis prompted us to update the last guidelines’ version. The objective was to align...

article

Parathyroid hormone contributes to the down-regulation of cytochrome P450 3A through the cAMP/PI3K/PKC/PKA/NF-κB signaling pathway in secondary hyperparathyroidism

Hiroshi Watanabe, Ryusei Sugimoto, Komei Ikegami, Yuki Enoki, more

Biochemical Pharmacology > 2017 > 145 > C > 192-201

Chronic kidney disease (CKD), which affects, not only renal clearance, but also non-renal clearance, is accompanied by a decline in renal function. Although it has been suggested that humoral factors, such as uremic toxins that accumulate in the body under CKD conditions, could be involved in the changes associated with non-renal drug clearance, the overall process is not completely understood. In...

article

Intracoronary acetylcholine application as a possible probe inducing J waves in patients with early repolarization syndrome

Toru Maruyama, Kazumasa Fujita, Kei Irie, Shouhei Moriyama, more

Journal of Arrhythmia > 2017 > 33 > 5 > 424-429

Acetylcholine is widely used for a diagnostic provocation test of coronary spasm in patients with vasospastic angina. Acetylcholine usually induces coronary vasodilatation mediated by muscarinic receptor activation, but sometimes it evokes vasoconstriction of coronary arteries where the endothelium is damaged. Early repolarization syndrome is characterized by a J wave observed at the end of the QRS...

article

Apoptosis induction of poly-S-nitrosated human serum albumin in resistant solid tumor under hypoxia can be restored by phosphodiesterase 5 inhibition

Mayumi Ikeda, Yu Ishima, Victor T.G. Chuang, Tsuyoshi Ikeda, more

Nitric Oxide > 2017 > 69 > C > 28-34

Poly-S-nitrosated human serum albumin (Poly-SNO-HSA) delivered and accumulated nitric oxide (NO) in tumors and induces apoptosis. Tumor hypoxia is strongly associated with malignant progression and tumor resistance to therapy. In this study, we examined the cytotoxic effect of Poly-SNO-HSA under hypoxia on the murine colon 26 adenocarcinoma (C26) cells in vitro and in vivo. Under hypoxia, at about...

article

Improved anticancer effects of albumin-bound paclitaxel nanoparticle via augmentation of EPR effect and albumin-protein interactions using S-nitrosated human serum albumin dimer

Ryo Kinoshita, Yu Ishima, Victor T.G. Chuang, Hideaki Nakamura, more

Biomaterials > 2017 > 140 > C > 162-169

In the latest trend of anticancer chemotherapy research, there were many macromolecular anticancer drugs developed based on enhanced permeability and retention (EPR) effect, such as albumin bound paclitaxel nanoparticle (nab- PTX, also called Abraxane^®). However, cancers with low vascular permeability posed a challenge for these EPR based therapeutic systems. Augmenting the intrinsic EPR effect with...

article

GENOME-WIDE ASSOCIATION STUDY OF ALZHEIMER DISEASE ENDOPHENOTYPES AT PRECLINICAL AND MCI STAGES

Jaeyoon Chung, Xulong Wang, Yiyi Ma, Toru Maruyama, more

Alzheimer's & Dementia > 2017 > 13 > 7(S) > P337-P338

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HUMAN SERUM ALBUMIN (41)
ANTIOXIDANT (16)
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INFONA - science communication portal

Search results for: Toru Maruyama

Case series of bradycardia, renal failure, atrioventricular nodal blockers, shock and hyperkalemia syndrome in patients with dementia

Constipation and heart failure: An overlooked but important linkage

A senile case of heart failure associated with hypermagnesemia induced by magnesium‐containing laxative agent

A Mannosylated, PEGylated Albumin as a Drug Delivery System for the Treatment of Cancer Stroma Cells

Evaluation of a new measurement method of indoxyl sulfate in hemodialysis patients

Albumin domain mutants with enhanced Aβ binding capacity identified by phage display analysis for application in various peripheral Aβ elimination approaches of Alzheimer's disease treatment

Prognostic significance of red cell distribution width in hospitalized older patients with heart failure or infection

Effect of Molten Metal Temperature on Mold Filling in Evaporative Pattern Casting

Influence of Tellurium Addition to Spheroidal Graphite Cast Iron on the Number of Graphite Particles

Antioxidant activities of chitosans and its derivatives in in vitro and in vivo studies

A metabarcoding survey for seasonal picophytoplankton composition in two coral reefs around Sesoko Island, Okinawa, Japan

Role of Parathyroid Hormone in Regulating Transporter and Metabolizing Enzyme Function

Does the prenatal bisphenol A exposure alter DNA methylation levels in the mouse hippocampus?: An analysis using a high-sensitivity methylome technique

Thioredoxin-albumin fusion protein prevents copper enhanced zinc-induced neurotoxicity via its antioxidative activity

2016 SOSORT guidelines: orthopaedic and rehabilitation treatment of idiopathic scoliosis during growth

Parathyroid hormone contributes to the down-regulation of cytochrome P450 3A through the cAMP/PI3K/PKC/PKA/NF-κB signaling pathway in secondary hyperparathyroidism

Intracoronary acetylcholine application as a possible probe inducing J waves in patients with early repolarization syndrome

Apoptosis induction of poly-S-nitrosated human serum albumin in resistant solid tumor under hypoxia can be restored by phosphodiesterase 5 inhibition

Improved anticancer effects of albumin-bound paclitaxel nanoparticle via augmentation of EPR effect and albumin-protein interactions using S-nitrosated human serum albumin dimer

GENOME-WIDE ASSOCIATION STUDY OF ALZHEIMER DISEASE ENDOPHENOTYPES AT PRECLINICAL AND MCI STAGES

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