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Glycerol-3-phosphate acyltransferase (GPAT) is considered as the rate-limiting enzyme of glycerolipid synthesis pathway and the core element in lysophosphatidic acid (LPA) synthesis. For understanding its catalytic mechanism, the structural biology study is expected, but is always hindered by obtaining crystals for X-ray diffraction analysis. In this study, a progressive strategy to optimize the crystal...
Crystallization is an important method to purify substances. It is widely applied in pharmacy and chemical industries. Penicillin crystallization is a complicated process with time-variable, uncertain and multivariable. The requirement of control in different stage is variable and there are some coupling between temperature and liquid level control in the tank. Traditional PID control is difficult...
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