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The dopamine D 2 receptor (D 2 R) regulates renal reactive oxygen species (ROS) production, and impaired D 2 R function results in ROS-dependent hypertension. Paraoxonase 2 (PON2), which belongs to the paraoxonase gene family, is expressed in various tissues, acting to protect against cellular oxidative stress. We hypothesized that PON2 may be involved in preventing excessive...