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The circular ssDNA genome originating from the bacterial phage phiX174 is efficiently packaged into an icosahedral DNA nanoframe to form a virus mimetic particle, which can passively infect the host E. coli bacteria through cell uptake. The structural rigidity, integrity, permeability, and programmability of the nanoframe are key features in the genome packaging and E. coli infection process, as reported...
Viral genomes can be compressed into a near‐spherical nanochamber to form infectious particles. In order to mimic the virus morphology and packaging behavior, we invented a programmable icosahedral DNA nanoframe with enhanced rigidity and encapsulated the phiX174 bacteriophage genome. The packaging efficiency could be modulated through specific anchoring strands adjustment, and the trapped phage genome...
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