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Resetting of the epigenome in human primordial germ cells (hPGCs) is critical for development. We show that the transcriptional program of hPGCs is distinct from that in mice, with co-expression of somatic specifiers and naive pluripotency genes TFCP2L1 and KLF4. This unique gene regulatory network, established by SOX17 and BLIMP1, drives comprehensive germline DNA demethylation by repressing DNA...
We examine the valuation effects of credit line agreements for a sample of firms during the period 1979-1989. We test the proposition that the magnitude of the stock price reaction to credit line announcements is dependent upon the firm's financial health or risk and the stated reason for the borrowing. Consistent with previous findings we report positive valuation effects to credit line announcements...
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