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Heterozygous mutations of the leucine-rich, glioma-inactivated 1 gene (LGI1) are the major known cause of partial epilepsy with auditory features (PEAF), accounting for roughly 50% of families. Recently, a partial gene microdeletion has been reported in a single family.To assess the contribution of LGI1 microrearrangements to the pathogenesis of PEAF, we screened 50 patients negative for point mutations...
Objective To estimate the interobserver reliability (IR) of the minimal diagnostic criteria for the parasomnias provided in the International Classification of Sleep Disorders Revised (ICSD–R). Methods Fifty consecutive subjects underwent a structured interview by three doctors based on the ICSD–R minimal criteria for the diagnosis of 13 parasomnias at any time in life. IR was calculated by Kappa...
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