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The effects of bicarbonate buffer (HCO -3 /CO 2 ) on the activity of the two K + channels proposed by some to control the pancreatic B-cell membrane response to glucose were studied. Single K + -channel records from membrane patches of cultured B-cells dissociated from adult rat islets exposed to a glucose- and bicarbonate-free medium (Na-Hepes in place of bicarbonate)...
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