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Previously we have shown the mitogenic effects of 4-Hydroxynonenal (HNE), a major lipid peroxidation product, on vascular smooth muscle cells (VSMC) in vitro. We now demonstrate by BrdU staining that HNE (2.5 μM) induced DNA synthesis in ex-vivo cultured rat aortas. In addition, HNE (2.5 and 5.0 μM) activated the transcription factor NF κ B in cultured human aortic VSMC. This effect was...
Background: Vascular complications of diabetes such as atherosclerosis are thought to result from increased sorbitol levels generated by aldose reductase (AR). Glucose-induced proliferation of vascular smooth muscle cells (VSMC) can be prevented by AR inhibitors (ARI). Since AR detoxifies lipid peroxidation products such as 4-hydroxynonenal (HNE), it potentially modulates the atherogenic effects...
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