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We have developed a novel radiogallium (Ga)–DOTA-based bivalent peptidic ligand targeting a chemokine receptor, CXCR4, for tumor imaging. A CXCR4 imaging probe with two CXCR4 antagonists (Ac-TZ14011) on Ga–DOTA core, Ga–DOTA-TZ2, was synthesized, and the affinity and binding to CXCR4 was evaluated in CXCR4 expressing cells in vitro. The affinity of Ga–DOTA-TZ2 for CXCR4 was 20-fold greater than the...
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