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A chiral β-amino acid containing three contiguous chiral centers was synthesized efficiently in 11 steps, employing enantio-enriched β-ketoester as a key intermediate, via stereoselective catalytic hydrogenation of the corresponding enamide. Stereoselective 1,4-addition of a methyl group and protonation were key to the preparation of the desired acid 12. Mild and efficient reaction conditions were...
Two previously reported P-chirogenic bisphospholane rhodium catalysts have been applied to the asymmetric hydrogenation of α- and β-acetamido dehydroamino acid derivatives. For α-acetamido dehydroamino acid derivatives, catalyst 4 produced very high enantiomeric excesses. These are contrasted with the previously reported enantiomeric excesses using catalyst 2. Both catalysts provide excellent enantioselectivity...
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