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The neuropeptides pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) are implicated in the photic entrainment of circadian rhythms in the suprachiasmatic nuclei (SCN). We now report that mice carrying a null mutation of the VPAC 2 receptor for VIP and PACAP (Vipr2 -/- ) are incapable of sustaining normal circadian rhythms of...
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