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Previous efficacy trials of SPf66 malaria vaccine have produced conflicting results in different populations. We report a randomised double-blind trial of the SPf66 vaccine conducted in Karen children aged 2–15 living in a malarious region of northwestern Thailand. Recombinant hepatitis B vaccine was used as a comparator. The study had a power of 90% to detect an efficacy of 30%, defined as a reduction...
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