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The supraspinal cellular events involved in H 1 -mediated hyperalgesia were investigated in a condition of acute thermal pain by means of the mouse hot-plate test. I.c.v. administration of the phospholipase C (PLC) inhibitors U-73122 and neomycin antagonized the hyperalgesia induced by the selective H 1 agonist FMPH. By contrast, U-73343, an analogue of U-73122 used as negative control,...
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