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The participation of hypothalamus–pituitary–adrenal axis in the gastroprotective effects of nociceptin/orphanin FQ (N/OFQ) has been investigated. Gastric mucosal lesions were induced by intragastric administration of 50% ethanol, 1 ml/rat. Rats received N/OFQ either by the intracerebroventricular (icv) route, at 3 µg/rat, or by the intraperitoneal (ip) route, at 10 µg/kg, 30 min before ethanol administration...
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