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In this talk I will review recent progress on Optofluidics at Cornell in three application spaces: mobile and global health, bioenergy, and nanoparticle analysis. Fundamental science will be described as well as routes to commercialization and deployment.
We create a smartphone accessory that is capable of optically reading out a detection reaction in a microfluidic chip. We test the accessory using an oligonucleotide conjugated gold nanoparticle colorimetric reaction targeted at detecting DNA from Kaposi's sarcoma associated herpesvirus, a cancer causing virus highly prevalent in some parts of the developing world.
We demonstrate optical waveguides, with integrated microfluidics, fabricated out of agarose hydrogel and capable of encapsulating live cells, thus allowing for the interaction of the direct optical mode with the biology rather than the weak evanescent field.
We study the thermal effects on flow and transport of species near 1550nm silicon photonic crystal nano-tweezers. With a silicon nitride based 1064nm alternative we reduce heating to 0.3K temperature increase and demonstrate molecular tweezing.
Silicon nitride photonic crystal resonators are designed for manipulating nanomaterials in water using 1064-nm laser. The material of the resonator and the operating wavelength were chosen to minimize thermal heating in the cavity.
Utilization of the evanescent fields of waveguides can lead a thousandfold reduction in photobioreactor size. Here we demonstrate an optofluidic chip for the characterization of bacterial bio-fuel production and growth in an evanescent field.
Resonant silicon photonics has recently enabled the direct optical tweezing of nano-objects on chip. Here we present a comprehensive evaluation of different resonator designs and demonstrate one with a stiffness of 22.3 pN nm−1 W−1.
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