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Human c‐KIT oncogene is known to regulate cell growth and proliferation, and thus, acts as a probable target in the treatment of gastrointestinal tumors (GIST). To identify small molecule ligands which can specifically bind with the G‐quadruplex (G4) in the c‐KIT promoter region as potential antitumor agents, we propose the combination of electrospray ionization–mass spectrometry (ESI‐MS), capillary...
One of the most cited limitations of biochemical detection is its poor sensitivity, owing to the relatively high complexity of micro‐samples. Moreover, some samples cannot be easily self‐replicated and their abundance cannot be increased through traditional technologies. Therefore, the preconcentration of low‐abundance samples is a key requirement for microfluidic biological analysis. In recent years,...