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Phosphoinositides are important signaling molecules that govern a large number of cellular processes such as proliferation, differentiation, membrane remodeling, and survival. Here we introduce a fully synthetic membrane-permeant derivative of a novel, easily accessible, and very potent phosphatidylinositol 3,4,5-trisphosphate [PtdIns(3,4,5)P 3 ] mimic: phosphatidylinositol 3,4,5,6-tetrakisphosphate...
A fluorescent protein from jellyfish changed the way life science research is performed today. Its discovery, the first expression in an animal, the determination of its structure, the details of the mechanism behind the fluorescence, and diversification of the fluorescent properties has made green fluorescent protein a unique tool in the biological sciences, and the scientists that made key contributions...
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