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ScFv antibody fragments are a promising alternative to full‐length antibodies for both therapeutic and diagnosis applications. They can be overexpressed in bacteria, which enables easy large scale production. Since scFv are artificial constructs, they are poorly soluble and prone to aggregation, which makes them difficult to manipulate and to refold. Here, stabilization and refolding of scFv fragments...
Back Cover: Aggregation‐prone antibody single‐chain variable fragments (scFv) are refolded from urea solutions in the presence of amphiphilic derivatives of poly(sodium acrylate) playing the role of artificial chaperons. Weak noncovalent interactions with the polymers impart solubility to partly‐folded scFv intermediates, resulting in recovery of the native‐like structure. This is reported by Nicolas...
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