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Upregulated synthesis of extracellular matrix (ECM) proteins by myofibroblasts is a common phenomenon in the development of fibrosis. Although the role of TGF-β in fibrosis development has been extensively studied, the involvement of other members of this superfamily of cytokines, the bone morphogenetic proteins (BMPs) in organ fibrosis has given contradictory results. BMP9 is the main ligand for...
This study investigates the proliferative effect of adenosine (ADO) in cultured mesangial cells, and the possible mediation of A 1 and/or A 2 receptors in this proliferative effect of ADO. ADO (10 −5 M) induced a significant increase in the [ 3 H]thymidine incorporation into DNA with respect to quiescent cells. This increase was similar to that obtained with the ADO...
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