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Diabetes mellitus (DM) is a well-known risk factor to develop tuberculosis (TB). Some reports indicate the serum concentrations of anti-TB drugs are lower in patients with TB and DM than those with TB only. Therefore, we developed a nonlinear mixed-effects model (NONMEM) to determine the population PK parameters of rifampin and assessed the effects of DM status in patients with TB. One-compartment...
Regulatory T cells (T reg ) increase in active tuberculosis (TB). However, whether T reg -mediated immune suppression affect the susceptibility to active TB or development of multidrug-resistant (MDR) TB is not yet clear. We compared circulatory T reg frequencies in drug susceptible (DS) and MDR TB before and after anti-TB treatment.Circulatory T reg frequencies were...
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