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Multimers of multicopy plasmids cause instability. They arise by homologous recombination and accumulate by over-replication in a process known as the dimer catastrophe. Dimers are resolved to monomers by site-specific recombination systems such as Xer-cer of plasmid ColE1. In addition, the Rcd checkpoint hypothesis proposes that a short transcript (Rcd) coded within ColE1 cer delays the division...
Dimers of low copy number plasmids must be resolved to monomers to prevent interference with active partition. For the P1 prophage this is achieved by the Cre site-specific recombinase acting at lox. Multimerisation of multicopy plasmids threatens stability via copy number depression, and multimers of ColE1 are resolved by XerCD-mediated recombination at cer. Xer-cer is constrained to multimer resolution...
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