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The long-term fate of fluorescent non-porous FITC-SiO 2 nanoparticles of various sizes (10–200 nm) and charge is studied in the presence of human dermal fibroblasts. Particle aggregates are formed in the culture medium and uptaken, at least partially, by macropinocytosis. The smallest particles have a strong impact on cell viability and genotoxic effects can be observed for negatively-charged...
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