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Hypoxia represents a remarkably exploitable target for cancer therapy, is encountered only in solid human tumors, and is highly associated with cancer resistance and recurrence. Here, a hypoxia‐activated mitochondria‐accumulated Ru(II) polypyridyl prodrug functionalized with conjugated azo (Az) and nitrogen mustard (NM) functionalities, RuAzNM, is reported. This prodrug has multimodal theranostic...
The Ru(II) complex cis,trans-[Ru(Me 2 NCH 2 CH 2 PPh 2 -P,N) 2 Cl 2 ] (1) has been characterized in the solid state and in solution. X-ray crystallography showed that complex 1 is monoclinic, space group C 2 /c; a = 36.0421, b = 11.4866, c = 31.0540 9; β = 104.556°. The structure refined to R = 0.0925 and Rw = 0.223. There are two independent...
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