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Modeling allows us to focus on the important components of a system under study, leaving aside the non-meaningful information. To study metabolic networks, we need to cre-ate a new model of the phenomena in order to start the simulations. Here, we propose a method for automating model-ing and simulation of biological cell processes using DEVS. We have built a parser and a model-generator in order...
The crystal structure of PA1994 from Pseudomonas aeruginosa, a member of the Pfam PF06475 family classified as a domain of unknown function (DUF1089), reveals a novel fold comprising a 15‐stranded β‐sheet wrapped around a single α‐helix that assembles into a tight dimeric arrangement. The remote structural similarity to lipoprotein localization factors, in addition to the presence of an acidic pocket...
The activation segment of protein kinases is structurally highly conserved and central to regulation of kinase activation. Here we report an atypical activation segment architecture in human MPSK1 comprising a β sheet and a large α-helical insertion. Sequence comparisons suggested that similar activation segments exist in all members of the MPSK1 family and in MAST kinases. The consequence of this...
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