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N-Methylimidazolium chloride is found to catalyze a coupling reaction between monophosphates and activated phosphorous–nitrogen intermediates such as a phosphorimidazolide and phosphoromorpholidate to form biologically important unsymmetrical pyrophosphate diesters. The catalyst is much more active, cheaper, and less explosive than 1H-tetrazole, known as the best catalyst for the pyrophosphate formation...
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