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Topical microbicide products are being developed for the prevention of sexually transmitted infections. These include vaginally-applied gels that deliver anti-HIV molecules. Gels may also provide partial barriers that slow virion diffusion from semen to vulnerable epithelium, increasing the time during which anti-HIV molecules can act. To explore the barrier function of microbicide gels, we developed...
We used a new optical imaging technique to compare human intravaginal coating distributions of Conceptrol® (Advanced Care Products, Brunswick, NJ) and Advantage™ (Columbia Laboratories, Aventuna, FL). These gels are surrogates for future microbicidal gels, differing in molecular structures and biophysical properties.For each protocol, a 3-mL gel bolus was inserted to the posterior fornix while the...
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