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Development of safe and effective gene delivery systems is essential in treating ocular genetic disorders. A hybrid nonviral system composed of a multifunctional lipid ECO and a G4 nanoglobule was designed for efficient gene delivery into RPE cells at low charge ratios. This system formed stable DNA nanoparticles at low N/P ratios, exhibited low cytotoxicity, and induced higher GFP expression in ARPE‐19...
Design and development of efficient non-viral gene delivery systems is critical to overcome various barriers for effective intracellular gene delivery. Eight new spermine-based protonatable surfactants were designed, synthesized and evaluated as non-viral pH-sensitive gene carriers. These carriers formed stable complexes with plasmid DNA at an N/P ratio as low as 2. The sizes of the carrier/pDNA nanoparticles...
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