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BackgroundAdenoviral‐directed enzyme prodrug therapy is a promising approach for head and neck cancer gene therapy. The challenges faced by this approach, however, comprise transient gene expression and dissemination of viruses to distant organs.
MethodsWe used recombinant silk‐elastinlike protein polymer (SELP) matrices for intratumoral delivery of adenoviruses containing both thymidine kinase‐1...
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