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The aim of the present study was to develop a once‐daily, delayed controlled release formulation for diltiazem. Developed formulation consists of two coated tablets inserted into a capsule; the first tablet is intended to produce a fast release profile, while the second tablet with a unique controlling membrane containing arabinogalactan as a channeling agent was designed to achieve a delayed controlled...
The coupling of amphotericin-B (AmB), a water-insoluble antifungal and antileishmanial agent, to arabinogalactan (AG) via tosylate or mesylate derivatives was investigated as a method for the conjugation of amino-containing drugs to polysaccharides. In the first step, AG was reacted with tosyl- or mesyl-chloride at different ratios to obtain tosylate or mesylate AG derivatives. AmB was conjugated...
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