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Background: The Saccharomyces cerevisiae protein Cks1 (cyclin-dependent kinase subunit 1) is essential for cell-cycle progression. The biological function of Cks1 can be modulated by a switch between two distinct molecular assemblies: the single domain fold, which results from the closing of a β-hinge motif, and the intersubunit β-strand interchanged dimer, which arises from the opening of the β-hinge...
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