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Ablation of the gene for phospholamban (PLB), a transmembrane peptide regulator for the cardiac sarcoplasmic reticulum Ca 2+ pump, in mice brings about a complete loss of the myocardial responses toβ-adrenergic agonists (e.gLuoet alCirc. Res.1994;75: 401). We have evaluated the functional significance of PLB-independent mechanisms in the myocardial responses toβ-adrenergic stimulation in isolated...
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