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Bacterial resistance to the aminoglycoside antibiotics is primarily the result of enzymatic deactivation of the drugs. The aminoglycoside N‐acetyltransferases (AACs) are a large family of bacterial enzymes that are responsible for coenzyme‐A‐facilitated acetylation of aminoglycosides. The gene encoding one of these enzymes, AAC(6′)‐Im, has been cloned and the protein (comprising 178 amino‐acid residues)...
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