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Amyloid β protein (Aβ)- and human group IIA secretory phospholipase A 2 (sPLA 2 -IIA)-induced neuronal cell death have been established as in vitro models for Alzheimer's disease (AD) and stroke. Both sPLA 2 -IIA and Aβ causes neuronal apoptosis by increasing the influx of Ca 2+ through L-type voltage-sensitive Ca 2+ channel (L-VSCC). In the present...
Secretory phospholipase A 2 (sPLA 2 ) exhibits neurotoxicity in the central nervous system. There are high-affinity binding sites of the porcine pancreatic group IB sPLA 2 (sPLA 2 -IB) in the brain. sPLA 2 -IB causes neuronal cell death via apoptosis in the rat cerebral cortex. Although apoptosis is triggered by an influx of Ca 2+ into neurons,...
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