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Targeting the interaction between PKC isoforms and their anchoring proteins can specifically regulate kinase activity. εV1‐2 and pseudoεRACK peptides, derived from the PKCε C2 domain, modulate its association with receptor for activated C‐kinase 2 (RACK2) and thus its function. Details of these interactions remain obscure, and we therefore investigated binding of these peptides using biophysical techniques...
SPRY domain‐containing SOCS box protein 2 (SPSB2) regulates inducible nitric oxide synthase (iNOS) by targeting it for proteasomal degradation. Inhibiting this interaction prolongs the intracellular lifetime of iNOS, leading in turn to enhanced killing of infectious pathogens such as bacteria and parasites. SPSB2 recognizes a linear motif (DINNN) in the disordered N‐terminus of iNOS, and ligands that...
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