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Saccharomyces cerevisiae Nhp6A and Nhp6B are chromatin architectural factors that belong to the high-mobility group box (HMGB) superfamily and appear to be functionally related to mammalian Hmgb1 [1]. They bind to the minor groove of double-stranded DNA in a non-sequence-specific manner [2] and thereby influence chromatin structure [3]. Previous work has implicated these proteins in a variety of nuclear...
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