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We have proposed that the yeast non-Mendelian elements [URE3] and [PSI] are prions, altered forms of Ure2p and Sup35p, respectively. Both are curable, but can arise again in the cured strains. The relation of theure2andsup35mutations to [URE3] and [PSI] is that expected of prions, not that expected of nucleic acid replicons. Overproduction of Ure2p and Sup35p increases by 100-fold the frequency with...
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