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Background and PurposeGNF‐351 is a potent aryl hydrocarbon receptor (AHR) antagonist that inhibits dioxin response element‐dependent and independent activities. Here, the absorption, metabolism and in vivo AHR antagonist activity of GNF‐351 were investigated.
Experimental ApproachLC‐MS metabolomics was used to analyse GNF‐351 metabolism in vitro and in vivo. Recombinant drug‐metabolizing enzymes...
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