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A homologue of the Escherichia coli GroEL apical domain was obtained from thermophilic eubacterium Thermus thermophilus. The domains share 70 % sequence identity (101 out of 145 residues). The thermal stability of the T. thermophilus apical domain (Tm>100°C as evaluated by circular dichroism) is at least 35°C greater than that of the E. coli apical domain (Tm=65°C). The crystal structure of a selenomethione-substituted...
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