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The chemotaxis system of Escherichia coli makes use of an extended two-component sensory response pathway in which CheA, an autophosphorylating protein histidine kinase (PHK) rapidly passes its phosphoryl group to CheY, a phospho-accepting response regulator protein (RR). The CheA→CheY phospho-transfer reaction is 100–1000 times faster than the His→Asp phospho-relays that operate in other (non-chemotaxis)...
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