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Hypoxanthine‐guanine phosphoribosyltransferase (HGPRTase), which is a key enzyme in the purine‐salvage pathway, catalyzes the synthesis of IMP or GMP from α‐d‐phosphoribosyl‐1‐pyrophosphate and hypoxanthine or guanine, respectively. Structures of HGPRTase from Thermus thermophilus HB8 in the unliganded form, in complex with IMP and in complex with GMP have been determined at 2.1, 1.9 and 2.2 Å resolution,...
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