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Purpose Novel tracers for the diagnosis of malignant disease with PET and PET/CT are being developed as the most commonly used 18F deoxyglucose (FDG) tracer shows certain limitations. Employing radioactively labelled glutamate derivatives for specific imaging of the truncated citrate cycle potentially allows more specific tumour imaging. Radiation dosimetry of the novel tracer BAY 85-8050, a glutamate...
Deregulated cell cycle progression is a hallmark of cancer. Accordingly, a major part of therapeutic drugs has been designed to inhibit cell proliferation and tumor growth. Metabolic imaging with positron emission tomography (PET) and the glucose analog 2′-[ 18 F]fluoro-2′-deoxyglucose (FDG) has been demonstrated to sensitively detect malignant tumors and to identify responding tumors early...
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