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We developed pH-responsive liposomes containing synthetic glutamic acid-based zwitterionic lipids and evaluated their properties both in vitro and in vivo with the aim of constructing an efficient liposome-based systemic drug delivery system. The glutamic acid-based lipids; 1,5-dihexadecyl N-glutamyl-l-glutamate (L1) and 1,5-dihexadecyl N,N-diglutamyl-lysyl-l-glutamate (L2) were synthesized as a pH-responsive...
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