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Long-term extrahepatic cholestasis in the rat induces ductular proliferation and fibrosis in the liver, portal hypertension, splenomegaly, portosystemic collateral circulation, and ascites. These splanchnic alterations could have an inflammatory pathophysiology.We measured serum levels of hepatobiliary injury markers and the acute phase proteins, alpha-1-major acid protein (α 1 -MAP) and alpha-1-acid...
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