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Abstract.3+1 technetium-99m mixed-ligand complexes as relevant to the development of a third generation of 99mTc radiopharmaceuticals were investigated in vivo and in vitro in the blood of rats. Surprisingly, in whole blood the complexes, which proved to be stable in saline, PBS of pH7.4 and in plasma, were converted into two radioactive, more hydrophilic metabolites. Small structural differences...
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