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Advanced in vitro systems such as multicellular spheroids and lab‐on‐a‐chip devices have been developed, but often fall short in reproducing the tissue scale and self‐organization of human diseases. A bioprinted artificial tumor model is introduced with endothelial and stromal cells self‐organizing into perfusable and functional vascular structures. This model uses 3D hydrogel matrices to embed multicellular...
Bioengineering
In article number 2303196, Twan Lammers, Horst Fischer, Fabian Kiessling, and co‐workers establish mesoscopic 3D vascularized tumors in perfusable bioreactors to mimic the onset of metastasis in vitro. The “High Tide” cover art exemplifies how a tumor spheroid triggers bioprinted endothelium's angiogenesis, akin to the moon's effect on the sea, resulting in high tides.
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